Heterogeneous factors in dementia with Parkinson's disease: IMP-SPECT study.
Parkinsonism Relat Disord
; 13(3): 174-81, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17145197
ABSTRACT
BACKGROUND:
Nature of the dementing process in Parkinson's disease, and particularly its relationship with Alzheimer's disease, diffuse Lewy body disease or frontal dementia remains controversial.OBJECTIVE:
We hypothesize that origins of dementia in Parkinson's disease are heterogeneous, so we compared cortical regional cerebral blood flow (rCBF) between Parkinson's disease patients with and without dementia. PATIENTS Forty consecutive patients with Hoehn-Yahr stage III or IV Parkinson's disease were used (13 patients had dementia (PDD group), and 27 patients had no dementia (PDND group)).RESULTS:
There were significant rCBF reductions in the left parietal association cortex and left frontal association cortex in PDD. Multiple logistic regression analysis demonstrated that only rCBF of the left frontal association cortex was significant. PDD patients were divided into three groups according to rCBF patterns frontal hypoperfusion group, Alzheimer's disease-like group, and diffuse Lewy body disease-like group.CONCLUSIONS:
Controversial study results involving PDD patients may be mainly due to heterogeneity in dementing processes in Parkinson's disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Córtex Cerebral
/
Demência
/
Inosina Monofosfato
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Parkinsonism Relat Disord
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão