Gene trap mutagenesis.
Handb Exp Pharmacol
; (178): 129-47, 2007.
Article
em En
| MEDLINE
| ID: mdl-17203654
ABSTRACT
Our ability to genetically manipulate the mouse has had a great impact on medical research over the last few decades. Mouse genetics has developed into a powerful tool for dissecting the genetic causes of human disease and identifying potential targets for pharmaceutical intervention. With the recent sequencing of the human and mouse genomes, a large number of novel genes have been identified whose function in normal and disease physiology remains largely unknown. Government-sponsored multinational efforts are underway to analyze the function of all mouse genes through mutagenesis and phenotyping, making the mouse the interpreter of the human genome. A number of technologies are available for the generation of mutant mice, including gene targeting, gene trapping and transposon, chemical or radiation-induced mutagenesis. In this chapter, we review the current status of gene trapping technology, including its applicability to conditional mutagenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mutagênese
/
Marcação de Genes
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos