Peptidomic analysis of human peripheral monocytes persistently infected by Chlamydia trachomatis.
Med Microbiol Immunol
; 196(2): 103-14, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17206452
ABSTRACT
Peptidomic analysis using Differential Peptide Display (DPD) of human peripheral blood mononuclear cells (PBMC) mock-infected or persistently infected by Chlamydia trachomatis (CT) revealed 10 peptides, expressed upon CT infection. Analysis of these 10 candidates by tandem mass spectrometry enabled the determination of seven candidates as fragments from the precursors (I) ferritin heavy chain subunit, (II) HLA class II histocompatibility antigen, (III) vimentin, (IV) indoleamine 2,3-dioxygenase, (V and VI) pre-B cell enhancing factor (PBEF), and (VII) Interleukin-8 (CXCL8). The identified candidates proved the presence of anti-bacterial and immunologically active monocytic proteins after CT infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Monócitos
/
Chlamydia trachomatis
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Med Microbiol Immunol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha