Alpha-2-macroglobulin-kallikrein complex: a temperature-sensitive mediator in contact-system-induced inflammation with a potential role in late and delayed hypersensitivity responses.
Int Arch Allergy Appl Immunol
; 96(2): 134-41, 1991.
Article
em En
| MEDLINE
| ID: mdl-1722780
ABSTRACT
Maximal complexing of alpha 2-macroglobulin (alpha 2M) and kallikrein (KK) occurs at a temperature of 22-24 rather than at 37 degrees C. The protease expressivity of the complex is also maximal at 22-24 degrees C. alpha 2M-KK complex, sustained permeability changes in guinea pig skin. These findings suggest that the complex, rather than free KK, could play a role in the kinin release reported in some late-phase reactions, some instances of delayed-type hypersensitivity and some cold-induced reactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alfa-Macroglobulinas
/
Calicreínas
/
Hipersensibilidade Tardia
/
Inflamação
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Int Arch Allergy Appl Immunol
Ano de publicação:
1991
Tipo de documento:
Article