Fatal interstitial pneumonitis associated with docetaxel administration in a patient with hormone-refractory prostate cancer.
Tumori
; 92(6): 542-4, 2006.
Article
em En
| MEDLINE
| ID: mdl-17260498
ABSTRACT
Taxanes are widely used chemotherapeutic agents with the potential to induce pulmonary injury through a variety of mechanisms. Patients receiving these agents are at risk of acute or subacute pulmonary damage. The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment. Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Doenças Pulmonares Intersticiais
/
Taxoides
/
Pulmão
/
Antineoplásicos
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Tumori
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália