Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.
Bioorg Med Chem Lett
; 17(8): 2184-7, 2007 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-17293109
ABSTRACT
Sulfonamide analogues of the potent CB1R inverse agonist taranabant were prepared and optimized for potency and selectivity for CB1R. They were variably more potent than the corresponding amide analogues. The most potent representative 22 had good pharmacokinetic and brain levels, but was modestly active in blocking CB1R agonist-mediated hypothermia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Receptor CB1 de Canabinoide
/
Moduladores de Receptores de Canabinoides
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos