Elongation and desaturation of arachidonic and eicosapentaenoic acids in rat liver. Effect of clofibrate feeding.
Biochim Biophys Acta
; 1086(3): 349-53, 1991 Nov 27.
Article
em En
| MEDLINE
| ID: mdl-1742327
ABSTRACT
The fatty acid elongation-desaturation ability of 5,8,11,14-eicosatetraenoic (204(n-6)) and 5,8,11,14,17-eicosapentaenoic (205(n-3)) acids was determined in both liver microsomal and light mitochondrial (rich in peroxisomes) fractions of untreated and clofibrate treated rats. The elongation and the subsequent desaturation steps were performed in the corresponding favorable media. 205(n-3) elongation was about 2-times more extensive than that of 204(n-6). Clofibrate feeding for 10 days resulted in a marked decrease in the elongation rate with the two substrates, while the delta 4 desaturation rate was increased. There were small differences in the elongation rate between the microsomal and light mitochondrial fractions, however, the relative delta 4 desaturation rate was higher in the light mitochondrial fraction than microsomes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Eicosapentaenoico
/
Clofibrato
/
Ácido Araquidônico
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
França