In vitro effects of growth factors and interferon-alpha on busulfan cytotoxicity.
Pediatr Hematol Oncol
; 24(3): 171-7, 2007.
Article
em En
| MEDLINE
| ID: mdl-17454786
ABSTRACT
An experimental approach to increasing the effectiveness of leukemia treatment with S-phase-specific cytotoxics is to increase the cycling of leukemia cells with growth factors. However, growth factors may have a different relationship with non-cell-cycle-specific agents. The authors examined the effects of granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), and interferon-alpha (INF-alpha) on the cytotoxic effects of the alkylating agent busulfan on the erythro-myeloid cell line K562. G-CSF and GM-CSF increased the proliferation and colony-forming ability of K562 cells and protected the cells from busulfan effects. INF-alpha decreased the colony-forming ability and proliferation of the K562 cells and demonstrated a possibly additive effect with busulfan. In the cell line K562, the growth factors G-CSF and GM-CSF protected the cells from the non-cell-cycle-specific alkylating agent busulfan, whereas IFN-alpha demonstrated an additive cytotoxic effect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bussulfano
/
Fator Estimulador de Colônias de Granulócitos
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
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Interferon-alfa
/
Antineoplásicos Alquilantes
/
Proliferação de Células
Limite:
Humans
Idioma:
En
Revista:
Pediatr Hematol Oncol
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Turquia