GAzer: gene set analyzer.
Bioinformatics
; 23(13): 1697-9, 2007 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-17468122
ABSTRACT
UNLABELLED Gene Set Analyzer (GAzer) is a web-based integrated gene set analysis tool covering previously reported parametric and non-parametric models. Based on a simulation test for the reported algorithms, we classified and implemented three main statistical methods consisting of the z-statistic, gene permutation and sample permutation for ten gene set categories including Gene Ontology (GO) for human, mouse, rat and yeast. This tool identifies significantly altered gene sets scored by z-statistics and P-values from the z-test or permutation test and provides q-values and Bonferroni P-values to correct multiple hypothesis testing. GAzer allows users to observe changes in expression of each gene in a gene set or to see the significance of the gene sets containing a gene(s) of interest, thus allowing interactive data analysis both at the gene and gene set level. Moreover, GAzer offers extensive annotation for each gene. AVAILABILITY:
The GAzer gene set analyzer is freely available at http//integromics.kobic.re.kr/GAzer/. SUPPLEMENTARY INFORMATION This can be found on the web page (http//integromics.kobic.re.kr/GAzer/supplement.jsp).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Interface Usuário-Computador
/
Software
/
Família Multigênica
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Internet
/
Perfilação da Expressão Gênica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2007
Tipo de documento:
Article