Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Epilepsia
; 48(5): 1015-8, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17509004
ABSTRACT
A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED-tolerant controls. HLA-B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-B
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Toxidermias
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Povo Asiático
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Epilepsia
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Anticonvulsivantes
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Epilepsia
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
China