Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.
J Heart Lung Transplant
; 26(6): 642-5, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17543791
ABSTRACT
Hyperacute rejection is an early complication of transplantation, caused by the presence in the recipient of pre-formed donor-directed antibodies (Ab). We report a case of fatal early graft dysfunction after lung transplantation in a female recipient with no anti-HLA Ab detected before transplantation. Further immunologic studies revealed the presence, in the pre-transplant serum, of low-titer anti-HLA Ab directed against the donor's HLA, detectable only by flow-cytometry screening for panel-reactive antibodies. This observation emphasizes the importance of sensitive Ab detection in patients awaiting lung transplantation. Women should be specifically targeted for such sensitive Ab detection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Enfisema Pulmonar
/
Transplante de Pulmão
/
Rejeição de Enxerto
/
Antígenos HLA
/
Isoanticorpos
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Heart Lung Transplant
Assunto da revista:
CARDIOLOGIA
/
TRANSPLANTE
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França