5-HT2A receptors are differentially expressed in bullfrog and rat retinas: a comparative study.
Brain Res Bull
; 73(4-6): 273-7, 2007 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-17562393
ABSTRACT
Expression of 5-hydroxytryptamine (5-HT) 2A receptor (5-HT2A) was studied in bullfrog and rat retinas by immunocytochemistry. In the bullfrog retina, 5-HT2A-immunoreactivity was observed in both the outer and inner plexiform layers (OPL and IPL). Double labeling experiments further showed that 5-HT2A was expressed in Müller cells stained by GFAP. Labeling for 5-HT2A was strong in the somata and endfeet and relatively weak in the major processes and fine branchets of Müller cells. In contrast, 5-HT2A immunoreactivity was hardly detected in the rat retina, and no rat Müller cells were labeled. Furthermore, immunocytochemical assay demonstrated that labeling for 5-HT was present in amacrine cells and displaced amacrine cells in the inner retina of bullfrog, but not in the rat retina. These results suggest that 5-HT may modulate retinal information processing via activating 5-HT2A expressed in neuronal and glial elements in bullfrog, but that such modulation is unlikely to occur in rat.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Receptor 5-HT2A de Serotonina
Limite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
2007
Tipo de documento:
Article