Nocistatin attenuated the nociceptin induced c-Fos expression in the mouse hippocampus.
Neuropeptides
; 41(4): 227-31, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17586043
ABSTRACT
Nocistatin and nociceptin/orphaninFQ (N/OFQ) are the two new peptides which may have roles in nociception, memory, anxiety, and other biological functions. Nocistatin acts as a functional antagonist to N/OFQ in several functions, but their neuro-anatomical sites of interaction are unknown. We investigated the effect of combined intracerebroventricular (i.c.v.) injection of nocistatin with N/OFQ, on N/OFQ induced c-Fos expression in the mouse hippocampus, using c-Fos immunohistochemistry. We found that co-injection of nocistatin with N/OFQ significantly attenuated N/OFQ induced c-Fos expression in the hippocampus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas c-fos
/
Peptídeos Opioides
/
Hipocampo
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Analgésicos Opioides
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuropeptides
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Singapura