Changes in endogenous antioxidant enzymes during cerebral ischemia and reperfusion.
Neurol Res
; 29(8): 877-83, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17588312
ABSTRACT
OBJECTIVE:
The purpose of this study was to investigate the role of catalase (Cat), glutathione S transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx) in cerebral ischemia induced by occluding the carotid arteries of male Wistar rats.METHODS:
The activities of the antioxidant enzymes Cat, GR, GPx and GST were measured in the cerebral cortex, cerebellum and hippocampus regions after varying periods of ischemia and reperfusion.RESULTS:
In all ischemia/reperfusion groups (0, 1 and 24 hours of reperfusion), the enzyme activities were found to be altered when compared to the sham-operated controls. The alterations were significant (p< or =0.05) in all reperfusion groups, particularly after 1 hour of reperfusion in all brain regions; however, maximum alterations were detected in the more vulnerable hippocampus.DISCUSSION:
Our findings indicate that the endogenous antioxidant enzymes are activated as soon as 1 hour after ischemia. In spite of significant up-regulation of these enzymes, a large number of neurons in selectively vulnerable regions of hippocampus undergo neurodegeneration. These biochemical changes suggest that vulnerability to oxidative stress in brain is region-specific. However, these changes which are adaptive or compromise the capacity of the brain to deal with the oxidative stress that could lead to neurodegeneration remains to be understood.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reperfusão
/
Isquemia Encefálica
/
Antioxidantes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neurol Res
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Índia