Diffusion and perfusion-weighted magnetic resonance imaging techniques in stroke recovery.

ABSTRACT

Most of the functional recovery after stroke takes place during the first three months after the insult. The neuronal mechanisms underlying this recovery are presently mostly unknown. However, in order to create efficient rehabilitation programs, it is of great importance to uncover these mechanisms. Multiple imaging techniques have been employed for the detection and characterization of ischemic lesions in the brain as well as monitoring of processes associated with stroke recovery. Diffusion and perfusion-weighted magnetic resonance imaging techniques are easy and fast to perform and provide significant information about the ischemic lesion and the hypoperfusion surrounding the lesion at both micro and macrovascular level. More sensitive detection and accurate characterization of the lesion will help in choosing the therapeutic strategies. Methods for monitoring brain function recovery will provide a better understanding of the basic mechanisms of plasticity in the brain, and will serve as a tool for the evaluation of therapeutic interventions, which may eventually include, for example, stem cell transplantation. With the help of these diagnostic tools it may become possible to tailor individual rehabilitation programs.