Skin and joint infection by Mycobacterium chelonae: rescue treatment with interferon gamma.
Joint Bone Spine
; 74(4): 385-8, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17613267
ABSTRACT
INTRODUCTION:
Atypical mycobacteria are environmental organisms that cause opportunistic infections in humans. CASE REPORT A 50-year-old electronics engineer sought advice about starting TNFalpha antagonist therapy for ankylosing spondylitis. Disease duration was 23 years and current treatment was methylprednisolone 4 mg/d. Atypical skin lesions and knee arthritis were noted. Fluid aspirated from the knee showed inflammatory properties and a few acid-fast bacteria, which a line probe assay identified as Mycobacterium chelonae. The same organism was found in a skin biopsy from a thigh lesion. Antimicrobial treatment was started immediately. Inadequate results 6 months later prompted synovectomy of the knee followed by interferon gamma, 50 microg/m(2) body surface area subcutaneously 3 times a week. After 16 months, there were no new skin or joint lesions, and the antimicrobials and interferon gamma were therefore discontinued.CONCLUSION:
This highly unusual case suggests that interferon gamma may be effective in patients with M. chelonae infection that fails to respond adequately to antimicrobials.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interferon gama
/
Mycobacterium chelonae
/
Artrite Reativa
/
Dermatopatias Bacterianas
/
Infecções por Mycobacterium não Tuberculosas
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Joint Bone Spine
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França