On the choice of genetic distance in spatial-genetic studies.
Genetics
; 177(1): 427-34, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17660571
ABSTRACT
We look at how to choose genetic distance so as to maximize the power of detecting spatial structure. We answer this question through analyzing two population genetic models that allow for a spatially structured population in a continuous habitat. These models, like most that incorporate spatial structure, can be characterized by a separation of timescales the history of the sample can be split into a scattering and a collecting phase, and it is only during the scattering phase that the spatial locations of the sample affect the coalescence times. Our results suggest that the optimal choice of genetic distance is based upon splitting a DNA sequence into segments and counting the number of segments at which two sequences differ. The size of these segments depends on the length of the scattering phase for the population genetic model.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Campylobacter jejuni
/
Cromossomos Bacterianos
/
Genoma Bacteriano
/
Genética Populacional
/
Modelos Genéticos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Genetics
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido