[Congenital heart disease associated with gastrointestinal malformations]. / Cardiopathies congénitales et malformations gastro-intestinales associées.
J Med Liban
; 55(2): 70-4, 2007.
Article
em Fr
| MEDLINE
| ID: mdl-17685118
ABSTRACT
OBJECTIVES:
To explore the association of congenital heart disease and malformations of the gastrointestinal tract/abdominal wall. PATIENTS ANDMETHODS:
Over seven years, 105 neonates presenting with congenital gastrointestinal/abdominal wall anomalies were explored for associated congenital heart disease. Sex, consanguinity, type of cardiac anomaly, type of gastrointestinal/abdominal wall anomaly, and chromosomal anomalies were all analyzed in order to find predisposing factors for this association.RESULTS:
Both anomalies were found in 38% of the patients, predominantly in males. Esophageal atresia and esotracheal fistulas were the most frequent anomalies (36%), followed by anal atresia (30.5%). The most common associated cardiac anomaly was the ventricular septal defect (37.5%). Chromosomal anomalies were correlated to the presence of congenital malformations, mainly atrioventricular septal defects (86%, p < 0.05) and intestinal atresia (54.4%, p < 0.05). First-cousin consanguinity was found in 13.3% of the children with gastrointestinal/abdominal wall anomalies. This percentage rises to 25% with the association of a cardiac anomaly and to 50% with VACTERL syndrome.CONCLUSION:
Congenital anomalies of the gastrointestinal tract/abdominal wall are associated with congenital heart disease in 38% of the cases. Consanguinity is a risk factor for the association of both these anomalies and for VACTERL syndrome. In case of gastrointestinal/abdominal wall anomalies, an associated cardiac anomaly must be actively sought, even if the clinical exam seems normal.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parede Abdominal
/
Trato Gastrointestinal
/
Cardiopatias Congênitas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
País/Região como assunto:
Asia
Idioma:
Fr
Revista:
J Med Liban
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Líbano