Highly efficient synthesis of functionalized indolizines and indolizinones by copper-catalyzed cycloisomerizations of propargylic pyridines.
J Org Chem
; 72(20): 7783-6, 2007 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-17718578
ABSTRACT
The copper-catalyzed cycloisomerizations of 2-pyridyl-substituted propargylic acetates and its derivatives are described, which offer an efficient route to C-1 oxygenated indolizines with a wide range of substituents under mild reaction conditions. The presented method could be readily applied to the synthesis of indolizinones through a cyclization/1,2-migration of tertiary propargylic alcohols.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Propanóis
/
Alcinos
/
Indolizinas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2007
Tipo de documento:
Article