Anti-HCV IgG avidity index in acute hepatitis C.
J Clin Virol
; 40(2): 110-5, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17720621
ABSTRACT
BACKGROUND:
The diagnosis of acute hepatitis C (AHC) is based on seroconversion to positive anti-HCV, which is usually not clinically possible.OBJECTIVE:
To determine if avidity of anti-HCV IgG can be used for the diagnosis of AHC infection. STUDYDESIGN:
We enrolled 40 consecutive patients with AHC, 16 drug addicts (IVDA) with exacerbation of chronic hepatitis C (IVDA e-CHC group), 21 non-IVDA with exacerbation of chronic hepatitis C (IVDA-free e-CHC group) and 40 with chronic hepatitis C (CHC group). HCV avidity index (HCV-AI) was determined by ELISA on sera pre-diluted 110 with 1M guanidine.RESULTS:
On admission, HCV-AI values were significantly lower in the AHC group (mean+/-S.D. 0.50+/-0.30) than in IVDA-free e-CHC group (0.97+/-0.08, p<0.0001), IVDA e-CHC group (0.90+/-0.29, p<0.0001) or CHC group (1.06+/-0.20, p<0.0001). An HCV-AI lower than 0.7 obtained within the 8th day of illness distinguished patients with AHC infection from the IVDA-free e-CHC cases. An increase in HCV-AI was observed in 24 (72.7%) of 33 in AHC group, in none of 13 in IVDA-free e-CHC group and in 3 (27.3%) of 11 in IVDA e-CHC group.CONCLUSION:
HCV-AI is useful in identifying AHC infection in patients observed within the 8th day from the onset of symptoms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Hepatite C
/
Anticorpos Anti-Hepatite C
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Virol
Assunto da revista:
VIROLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália