Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum.
Nat Cell Biol
; 9(10): 1160-6, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17828249
ABSTRACT
The formation of the nuclear envelope (NE) around chromatin is a major membrane-remodelling event that occurs during cell division of metazoa. It is unclear whether the nuclear membrane reforms by the fusion of NE fragments or if it re-emerges from an intact tubular network of the endoplasmic reticulum (ER). Here, we show that NE formation and expansion requires a tubular ER network and occurs efficiently in the presence of the membrane fusion inhibitor GTPgammaS. Chromatin recruitment of membranes, which is initiated by tubule-end binding, followed by the formation, expansion and sealing of flat membrane sheets, is mediated by DNA-binding proteins residing in the ER. Thus, chromatin plays an active role in reshaping of the ER during NE formation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Retículo Endoplasmático
/
Membrana Nuclear
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos