Immunodeficiencies due to defects of class-switch recombination.
Immunol Res
; 38(1-3): 68-77, 2007.
Article
em En
| MEDLINE
| ID: mdl-17917012
ABSTRACT
Maturation of the antibody response is dependent on class-switch recombination (CSR) and somatic hypermutation (SHM), that modify the structure and the affinity of immunoglobulins, respectively. The cellular and molecular mechanisms involved in these processes have long remained obscure. During the last years, careful investigation of a cohort of rare patients with defective antibody responses have led to the identification of several genes that are critically involved in CSR and SHM. At the same time, recognition that defective maturation of antibody responses may result from different mechanisms, has been essential to better define prognosis and to tailor more appropriate and specific forms of treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Switching de Imunoglobulina
/
Hipermutação Somática de Imunoglobulina
/
Síndromes de Imunodeficiência
/
Formação de Anticorpos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Immunol Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália