Differences in pHi recovery in CO2-chemosensitive and non-chemosensitive cells: predictions from a mathematical model.

In this paper, we present a mathematic model designed to identify potential mechanisms responsible for the observed differences in pHi recovery in CO(2)-chemosensitive versus non-chemosensitive cells. The model suggests that differences in pHi regulation may be dependent upon differences in the activation set-point of the internal modifier site of the Na(+)/H(+) exchanger (NHE).