Gain of multiple copies of the CBFB gene: a new genetic aberration in a case of granulocytic sarcoma.
Cancer Genet Cytogenet
; 179(1): 62-5, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17981216
ABSTRACT
Granulocytic sarcomas (GS) are tumor masses of immature myeloid cells presenting at an extramedullary site, mainly the skin, bone, and lymph node. They are often associated with acute myeloid leukemia (AML) with monoblastic or myelomonocytic differentiation, including either AML M2 with t(8;21)(q22;q22) or AML M4Eo with inv(16)(p13q22). We present a case diagnosed with GS associated with AML M4 that presented a normal karyotype with conventional cytogenetic analysis. Although the myeloblasts did not show the inv(16)(p13q22) (CBFB/MYH11), a gain of multiple copies of the CBFB gene was detected with fluorescence in situ hybridization analysis. To our knowledge, no cases with this rare genetic anomaly have been previously described.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dosagem de Genes
/
Duplicação Gênica
/
Sarcoma Mieloide
/
Subunidade beta de Fator de Ligação ao Core
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Espanha