Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Science
; 318(5853): 1141-3, 2007 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-18006747
ABSTRACT
CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as an adjuvant during induced immune responses, and Tim-3 ligation induced distinct signaling events in T cells and dendritic cells; the latter finding could explain the apparent divergent functions of Tim-3 in these cell types. Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1 immunity and may be able to influence a range of inflammatory conditions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Receptores Imunológicos
/
Células Th1
/
Mediadores da Inflamação
/
Proteínas de Membrana
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos