Aminoacyl-tRNA surveillance by EF-Tu in mammalian mitochondria.
Nucleic Acids Symp Ser (Oxf)
; (51): 41-2, 2007.
Article
em En
| MEDLINE
| ID: mdl-18029576
ABSTRACT
Aminoacyl-tRNA synthetases specifically recognize their cognate tRNAs and ensure the accuracy of translation. However, in mammalian mitochondria, seryl-tRNA synthetase (mt SerRS) significantly misacylates tRNA(Gln), indicating the presence of another mechanism to be required to maintain the fidelity of mitochondrial protein synthesis. We have revealed that mammalian mitochondrial elongation factor Tu (mt EF-Tu) tends to interact with seryl-tRNA(Gln) with lower affinity than glutaminyl-tRNA(Gln) and seryl-tRNA(Ser). This result proposes that mt EF-Tu has a critical role to maintain the translational fidelity by surveillance of aminoacyl-tRNAs for quality control.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminoacil-RNA de Transferência
/
Fator Tu de Elongação de Peptídeos
/
Proteínas Mitocondriais
/
Aminoacilação de RNA de Transferência
/
Mitocôndrias
Tipo de estudo:
Screening_studies
Limite:
Animals
Idioma:
En
Revista:
Nucleic Acids Symp Ser (Oxf)
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão