[Mathematical models for the study of electromechanical and mechanoelectrical coupling in the myocardium].
Ross Fiziol Zh Im I M Sechenova
; 93(9): 945-68, 2007 Sep.
Article
em Ru
| MEDLINE
| ID: mdl-18030795
ABSTRACT
Mathematical models have been developed to describe interactions of electrical, mechanical and chemical processes in cardiomyocytes. The models simulate wide range of experimental data on excitation-contraction coupling and, more importantly, on mechanoelectric feedback in heart muscle. The model results clearly show that mechano-dependence of intracellular calcium handling due to cooperative effects of contractile proteins activation plays a key role in cardiac mechanoelectric coupling. At the same time, mechanosensitive currents can also contribute to action potential responses to mechanical perturbations. Using this model to study the heterogeneous myocardium we have shown that temporal and functional electromechanical heterogeneity of coupled cardiomyocytes can essentially determine the myocardium contractility. Optimization of the electromechanical function of contractile system emerges from the fine coordination between the activation sequence of cardiomyocytes, their local electromechanical properties and the mechanical interaction during contraction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Miócitos Cardíacos
/
Mecanotransdução Celular
/
Sistema de Condução Cardíaco
/
Modelos Teóricos
/
Contração Miocárdica
Limite:
Animals
/
Humans
Idioma:
Ru
Revista:
Ross Fiziol Zh Im I M Sechenova
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article