[Antibiotic therapy of suppurative-inflammatory lesions of the bronchi with endobronchial use of low-frequency ultrasonic energy]. / Antibiotikoterapiia gnoino-vospalitel'nykh porazhenii bronkhov s éndobronkhial'nym ispol'zovaniem énergii nizkochastotnogo ul'trazvuka.

Gentamycin pharmacokinetics and its concentrations in bronchial secretion were studied in routine endobronchial introduction versus endobronchial aerosol spraying with application of low-frequency ultrasound. The latter technique warranted gentamycin concentrations in bronchial secretion 24 hours after the procedure many times that minimal for inhibition of the pathogen isolated. Secretion levels of gentamycin remained high for 4 days. No side effects were reported. The findings provide evidence in favor of endobronchial aerosol spraying of the drugs for treatment of purulent endobronchitis in bronchiectasis and chronic bronchitis.