Pharmacology of neurotransmitter transport into secretory vesicles.
Handb Exp Pharmacol
; (184): 77-106, 2008.
Article
em En
| MEDLINE
| ID: mdl-18064412
ABSTRACT
Many neuropsychiatric disorders appear to involve a disturbance of chemical neurotransmission, and the mechanism of available therapeutic agents supports this impression. Postsynaptic receptors have received considerable attention as drug targets, but some of the most successful agents influence presynaptic processes, in particular neurotransmitter reuptake. The pharmacological potential of many other presynaptic elements, and in particular the machinery responsible for loading transmitter into vesicles, has received only limited attention. The similarity of vesicular transporters to bacterial drug resistance proteins and the increasing evidence for regulation of vesicle filling and recycling suggest that the pharmacological potential of vesicular transporters has been underestimated. In this review, we discuss the pharmacological effects of psychostimulants and therapeutic agents on transmitter release.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vesículas Secretórias
/
Proteínas Vesiculares de Transporte de Neurotransmissores
/
Proteínas de Transporte de Neurotransmissores
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Noruega