Motor coordination deficits in mice lacking RGS9.
Brain Res
; 1190: 78-85, 2008 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-18073128
ABSTRACT
RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ataxia
/
Reflexo de Sobressalto
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Comportamento Animal
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Aprendizagem em Labirinto
/
Proteínas RGS
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos