Metastasis tumor antigen 1 is involved in the resistance to heat stress-induced testicular apoptosis.
FEBS Lett
; 582(6): 869-73, 2008 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-18282480
ABSTRACT
Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously reported upregulation of p53 in mouse cryptorchidism. Furthermore, in vitro over-expression of Mta1 could remarkably elevate the resistance capability of spermatogenic tumor cells against heat-induced apoptosis with a marked impairment of p53 expression. These findings indicate that Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testículo
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Fatores de Transcrição
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Proteína Supressora de Tumor p53
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Apoptose
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Temperatura Alta
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2008
Tipo de documento:
Article