Sonication induced intermediate in prion protein conversion.
Protein Pept Lett
; 15(2): 206-11, 2008.
Article
em En
| MEDLINE
| ID: mdl-18289112
ABSTRACT
We have observed that hamster prion protein (PrP(C)) undergoes conformational changes on exposure to heat or sonication. If a sonication induced new conformer is seeded with a small amount of its abnormal pathogenic isoform (PrP(Sc)) it undergoes a significant conversion to a proteinase-resistant isoform. This suggests the presence of a third stable PrP conformer, which may be intermediate in the conversion of PrP(C) to PrP(Sc).
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
/
Sonicação
/
Proteínas PrPSc
/
Proteínas PrPC
/
Isoformas de Proteínas
Limite:
Animals
Idioma:
En
Revista:
Protein Pept Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos