An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy.
Clin Neurol Neurosurg
; 110(5): 514-7, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18342435
ABSTRACT
We report a case of a 9-month pregnant woman who presented acute psychiatric and neurological symptoms with extensive involvement of the white matter on MRI and no oligoclonal bands on CSF examination. Despite high doses of intravenous steroids, plasmapheresis and immunosuppressive drugs, a fatal outcome (coma) was noted 8 months later. Neuropathological examination confirmed the diagnosis of Marburg's type of multiple sclerosis showing sharp-edged lesions of demyelination, giant astrocytes, numerous macrophages and little perivascular inflammation. We discuss the definition and limits of the Marburg entity with reference to acute disseminated encephalomyelitis, impact of pregnancy, unusual MRI features, neuropathology and treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Encéfalo
/
Encefalomielite Aguda Disseminada
/
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Clin Neurol Neurosurg
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França