No evidence of the APC D1822V missense variant's pathogenicity in Tunisian patients with sporadic colorectal cancer.
Pathol Biol (Paris)
; 57(3): e67-71, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-18343606
ABSTRACT
OBJECTIVES:
Sporadic colorectal cancer is influenced by numerous single nucleotide polymorphisms (SNPs), each with minor effects on the cancer risk. This study seeks to determine whether there is any association of the I1307K, E1317Q and D1822V variants within the Adenomatous polyposis coli gene (APC) and risk to develop colorectal cancer in Tunisian population.METHODS:
Direct sequencing was used to investigate three SNPs in the APC in 48 Tunisian sporadic colorectal cancer cases and 63 controls.RESULTS:
There was no statistically significant association between the I1307K, E1317Q and D1822V variants investigated and colorectal cancer risk.CONCLUSION:
The lack of association may show that these variants selected for this study are not involved in the colorectal carcinogenic process. Otherwise, the eventual biological effect is so little to go undetected, unless increasing the sample size.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Neoplasias Colorretais
/
Genes APC
/
Mutação de Sentido Incorreto
/
Polimorfismo de Nucleotídeo Único
/
Proteína da Polipose Adenomatosa do Colo
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
Pathol Biol (Paris)
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Tunísia