Yersinia pestis caf1 variants and the limits of plague vaccine protection.
Infect Immun
; 76(5): 2025-36, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18347051
ABSTRACT
Yersinia pestis, the highly virulent agent of plague, is a biological weapon. Strategies that prevent plague have been sought for centuries, and immunization with live, attenuated (nonpigmented) strains or subunit vaccines with F1 (Caf1) antigen is considered effective. We show here that immunization with live, attenuated strains generates plague-protective immunity and humoral immune responses against F1 pilus antigen and LcrV. Y. pestis variants lacking caf1 (F1 pili) are not only fully virulent in animal models of bubonic and pneumonic plague but also break through immune responses generated with live, attenuated strains or F1 subunit vaccines. In contrast, immunization with purified LcrV, a protein at the tip of type III needles, generates protective immunity against the wild-type and the fully virulent caf1 mutant strain, in agreement with the notion that LcrV can elicit vaccine protection against both types of virulent plague strains.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peste
/
Proteínas de Bactérias
/
Yersinia pestis
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Vacina contra a Peste
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Proteínas Citotóxicas Formadoras de Poros
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Antígenos de Bactérias
Limite:
Animals
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos