Insulin signal transduction pathways.
Trends Endocrinol Metab
; 5(9): 369-76, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-18407232
ABSTRACT
Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular signaling pathways. This article reviews recent progress in elucidating the detailed pathways that lead from the insulin receptor to the ultimate biologic actions of insulin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Trends Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Estados Unidos