Functional integration of transcriptional and RNA processing machineries.
Curr Opin Cell Biol
; 20(3): 260-5, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18436438
ABSTRACT
Cotranscriptional RNA processing not only permits temporal RNA processing before the completion of transcription but also allows sequential recognition of RNA processing signals on nascent transcripts threading out from the elongating RNA polymerase II (RNAPII) complex. Rapid progress in recent years has established multiple contacts that physically connect the transcription and RNA processing machineries, which centers on the C-terminal domain (CTD) of the largest subunit of RNAPII. Although cotranscriptional RNA processing has been substantiated, the evidence for 'reciprocal' coupling starts to emerge, which emphasizes functional integration of transcription and RNA processing machineries in a mutually beneficial manner for efficient and regulated gene expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
RNA Polimerase II
/
RNA Mensageiro
/
Regulação da Expressão Gênica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos