Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).
J Nat Prod
; 71(6): 981-4, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18547114
ABSTRACT
A polyhydroxylated cyclic 13-membered sulfoxide (1) was isolated from an aqueous extract of Kothala-himbutu ( Salacia reticulata WIGHT). The structure of compound 1 was elucidated by 1D and 2D NMR and APCI-MS methods. The alpha-glucosidase inhibitory activity of compound 1 (IC 50 maltase, 0.227 microM; sucrase, 0.186 microM; isomaltase, 0.099 microM) was much greater than the inhibitory activity of salacinol and kotalanol, which were previously isolated from Kothala-himbutu.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Compostos de Enxofre
/
Salacia
/
Inibidores de Glicosídeo Hidrolases
/
Compostos Heterocíclicos com 1 Anel
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão