Serotonin type 1D receptors (5HTR) are differentially distributed in nerve fibres innervating craniofacial tissues.
Cephalalgia
; 28(9): 933-44, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18557979
ABSTRACT
We tested the hypothesis that the 5HT(1D)R, the primary antinociceptive target of triptans, is differentially distributed in tissues responsible for migraine pain. The density of 5HT(1D)R was quantified in tissues obtained from adult female rats with Western blot analysis. Receptor location was assessed with immunohistochemistry. The density of 5HT(1D)R was significantly greater in tissues known to produce migraine-like pain (i.e. circle of Willis and dura) than in structures in which triptans have no antinociceptive efficacy (i.e. temporalis muscle). 5HT(1D)R-like immunoreactivity was restricted to neuronal fibres, where it colocalized with calcitonin gene-related peptide and tyrosine hydroxylase immunoreactive fibres. These results are consistent with our hypothesis that the limited therapeutic profile of triptans could reflect its differential peripheral distribution and that the antinociceptive efficacy reflects inhibition of neuropeptide release from sensory afferents. An additional site of action at sympathetic efferents is also suggested.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Facial
/
Triptaminas
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Círculo Arterial do Cérebro
/
Artéria Carótida Primitiva
/
Receptor 5-HT1D de Serotonina
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Dura-Máter
/
Transtornos de Enxaqueca
/
Fibras Nervosas
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Cephalalgia
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos