[SPECT-CT: a new tool for localisation of sentinel lymph nodes in breast cancer patients]. / SPECT-TAC: una nueva herramienta para la localización del ganglio centinela en pacientes con cáncer de mama.
Rev Esp Med Nucl
; 27(3): 183-90, 2008.
Article
em Es
| MEDLINE
| ID: mdl-18570860
ABSTRACT
INTRODUCTION:
Sentinel lymph node biopsy has become a widely accepted procedure for axillary lymph node staging in patients with breast cancer.AIM:
The aim of this study was to determine the advantages of using SPECT-CT instead of planar scintigraphy in the presurgical localisation of sentinel lymph nodes.METHODS:
We prospectively included 25 consecutive patients with breast cancer who were admitted to our department for SLN localisation. Patients were divided into two groups, depending on whether neoadjuvant chemotherapy had been received (B, n = 6) or not (A, n = 19). Four doses (1.0 mCi each) of 99mTc-nanocolloid were injected intradermallly in all patients, and SPECT-CT and planar images were acquired. All patients underwent surgery and SLN localisation with a hand-held gamma probe. Any axillary "hot spots" were resected. The kappa index (ki) was calculated using surgical findings as the gold standard.RESULTS:
In group A, the SLN was correctly detected in 17/19 patients (89.5 %) with SPECT-CT and in 12/19 (63.2 %) with planar images. The correlation between SPECT-CT and surgical findings (ki 0.91) was better than between planar images and surgical findings (ki 0.57). In group B, the results of SPECT-CT and planar images were identical, with accurate localisation of the SLN in 5/6 patients (ki 0.76).CONCLUSIONS:
The results of this study suggest that SPECT-CT may be useful for locating the SLN in breast cancer patients, as it provides accurate localization of the SLN with useful anatomical information. This may allow the surgeon to search exclusively for SLN viewed on SPECT-CT, and avoid false negative and false positive results.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Tomografia Computadorizada por Raios X
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Carcinoma Ductal de Mama
/
Biópsia de Linfonodo Sentinela
/
Estadiamento de Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
Es
Revista:
Rev Esp Med Nucl
Assunto da revista:
MEDICINA NUCLEAR
Ano de publicação:
2008
Tipo de documento:
Article