[Adjuvant chemotherapy followed by conformal chemoradiotherapy in gastric carcinoma]. / Chimiothérapie adjuvante suivie d'une chimioradiothérapie conformationnelle dans les cancers de l'estomac.
Cancer Radiother
; 12(8): 775-80, 2008 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-18571967
ABSTRACT
PURPOSE:
Analysis of the feasibility and results of adjuvant chemotherapy followed by conformal chemoradiotherapy after surgery for gastric carcinoma. PATIENTS ANDMETHODS:
Twenty-six patients (R0 or R1) were treated postoperatively by three cycles of 5-fluorouracil (5-FU) and cisplatin, followed by a concomitant association of LV5FU2 chemotherapy with a conformal radiotherapy of 45 Gy.RESULTS:
The tumor was classified pT3-T4 in 77% of the patients and 92.5% had a nodal involvement (pN1 54%; pN2 31%). FEASIBILITY (1) Adjuvant chemotherapy nausea/vomiting grade II/III 12 patients (48%); neutropenia grade III/IV two patients; completed in all patients, except one. (2) Chemoradiotherapy nausea/vomiting grade II/III 10 patients; diarrhea grade II/3 two patients; oesophagitis grade II/III two patients; myocardial infarction/pulmonary embolism two patients. All patients except one received the planned dose of 45Gy. Radiotherapy was interrupted in six cases, with a median duration of 14 days. Survival with a median follow-up of 30 months, 65% of the patients were alive without disease; median survival was 32 months.CONCLUSION:
This postoperative schedule was judged feasible. It allowed the deliverance of a more intensified chemotherapy than the classical schedule. Its clinical benefit must be evaluated in a phase III trial.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Radioterapia Conformacional
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
Fr
Revista:
Cancer Radiother
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França