Expression of parathyroid-hormone- related protein in the partially obstructed rabbit bladder.
Urol Int
; 81(1): 82-6, 2008.
Article
em En
| MEDLINE
| ID: mdl-18645277
ABSTRACT
INTRODUCTION:
Parathyroid-hormone-related protein (PTHrP) is considered as an autocrine/paracrine regulator of growth and/or differentiation in normal and malignant tissues. We determined the distribution and density of the expression of PTHrP in the rabbit bladder during growth in response to partial outlet obstruction and its relation with the smooth muscle/collagen ratio. MATERIALS ANDMETHODS:
A total of 30 male New Zealand White rabbits were studied. After 7, 14, 28 or 56 days of obstruction, 6 rabbits per group were sacrificed and the bladder extracted. Six sham-operated rabbits served as controls. The expression and localization of PTHrP or collagen type III were detected by immunohistochemistry using specific antibodies.RESULTS:
The levels of PTHrP were progressively increased by 14 days of obstruction, whereas they decreased after 14 days, although the PTHrP positivity was higher than in sham controls by 28 and 56 days of obstruction. PTHrP staining was related to the smooth muscle/collagen ratio, both showing a peak in rabbits obstructed for 14 days.CONCLUSIONS:
These data indicate that PTHrP may play an important regulatory role in the cellular and vascular response to partial outlet obstruction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Regulação da Expressão Gênica
/
Proteína Relacionada ao Hormônio Paratireóideo
/
Músculo Liso
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Urol Int
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos