Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.
J Nat Prod
; 71(8): 1481-4, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18681480
ABSTRACT
The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5alpha-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3-10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC 50 8.1-48.5 microM) and butyrylcholinesterase (IC 50 0.4-4.0 microM). Compounds 1-10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pregnanos
/
Buxaceae
/
Alcaloides
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Alemanha