Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS study.
Eur J Gynaecol Oncol
; 29(4): 327-32, 2008.
Article
em En
| MEDLINE
| ID: mdl-18714563
ABSTRACT
PURPOSE:
To compare Hybrid Capture II (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples.METHODS:
Patients were submitted to Pap smears, visual inspection with acetic acid (VIA) and HC2 for hr-HPV.RESULTS:
A total of 1,081 HC2 tests for HR-HPV were performed 770 (71.2%) samples were collected by a physician and 311 (28.8%) were self-collected by the patients. In detecting any cervical lesion, the sensitivity of HC2 collected by a physician was higher (92.86%) than that (37.5%) in the self-sampling group. Negative predictive value (NPV) was high for both, 99.69% and 93.75%, respectively. Using the CIN2 cutoff, performance of HC2 was significantly improved 92.9% and 62.5%, respectively. HC2 specificity for any cervical lesion and for CIN2 or higher were close to 90% in both groups.CONCLUSIONS:
Self-sampled HPV testing is a powerful option to increase the detection of cervical lesions in women segregated from prevention programs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esfregaço Vaginal
/
Neoplasias do Colo do Útero
/
Infecções por Papillomavirus
/
Teste de Papanicolaou
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Gynaecol Oncol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil