[Optimization for formulation matrix proportion of xiangyu cataplasm by uniform design].

ABSTRACT

OBJECTIVE: To optimize the matrix formulation of cataplasm used to cure infantile diarrhea. METHODS: The optimum proportion of matrix for the preparation technology process of cataplasm was selected by uniform design and SPSS regression analysis. A check-up for adhibition , peeling strength, nonflowing, content of cream was founded. RESULTS: The best matrix's prescription gelatin CMC-Na PANA kaolin aluminum trichloride citric acid PVP K-30 PEG400 trimethylene glycol tween-80 was 0.25 0.1 0.2 1.5 0.4 0.6 0.8 2 1 0.5. CONCLUSION: The preparation technique of cataplasm is feasible, and its quality is steerable, it is a safe and effective transdermal-drug delivery system.