Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways.
J Agric Food Chem
; 56(21): 9892-8, 2008 Nov 12.
Article
em En
| MEDLINE
| ID: mdl-18841980
ABSTRACT
The bioactive polysaccharides (named ZPF1) from yam ( Dioscorea batatas) were chemically determined, suggesting repeating beta-1,4-mannan as mainly having a feature of acetylation on C2-OH and C3-OH, around 28%. The ZPF1 participated in the stimulation of murine wild-type macrophages predominantly in tumor necrosis factor-alpha (TNFalpha). Toll-like receptor 4 is proved to be one of the cellular receptors in ZPF1-mediated TNFalpha secretion. Reactive oxygen species transmission and PI3-kinase are found necessary for regulating TNFalpha secretion by ZPF1 stimulation. Moreover, we found that extracellular signal-regulated kinase 1/2, Jun N-terminal kinase 1/2, and p38 mitogen-activated protein kinase play important roles in the regulation of TNFalpha secretion in ZPF1-stimulated macrophages.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Proteínas Quinases
/
Transdução de Sinais
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Fator de Necrose Tumoral alfa
/
Dioscorea
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Receptor 4 Toll-Like
Limite:
Animals
Idioma:
En
Revista:
J Agric Food Chem
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Taiwan