11,12-Secoprostaglandins. 2. N-acyl-N-alkyl-7-aminoheptanoic acids.
J Med Chem
; 20(1): 44-8, 1977 Jan.
Article
em En
| MEDLINE
| ID: mdl-189029
ABSTRACT
A series of N-acyl-N-alkyl-7-aminoheptanoic acids has been prepared and evaluated for their ability to mimic the natural prostaglandins in certain biological systems. These compounds can be regarded as 8-aza-11,12-secoprostaglandins and, indeed, most of them stimulate cAMP formation in the mouse ovary assay, just as is observed with the natural prostaglandins. Selected compounds from this series also have been studied and shown to have prostaglandin-like effects in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prostaglandinas
/
Ácidos Graxos
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1977
Tipo de documento:
Article