A clinicopathologic series of primary graft failure after Descemet's stripping and automated endothelial keratoplasty.
Ophthalmology
; 116(4): 609-14, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-18962919
ABSTRACT
PURPOSE:
To characterize the clinical and histologic features of primary graft failure after Descemet's stripping and automated endothelial keratoplasty (DSAEK).DESIGN:
Retrospective observational case series.PARTICIPANTS:
Sixteen cases of DSAEK graft failure from 15 patients, all with detailed histologic examination of failed graft tissue.METHODS:
Hematoxylin-eosin, periodic acid-Schiff staining, and light microscopy were used to examine the failed DSAEK graft tissue from all patients. MAIN OUTCOMEMEASURES:
Examination of specimens for corneal endothelial cell viability and host-donor interface characteristics.RESULTS:
Clinical history revealed that 88% (14/16) of studied DSAEK grafts detached before failure, and pathologic examination found that 75% (12/16) of failed grafts had atrophic corneal endothelium. Examples of residual host Descemet's membrane in the graft site and improper donor trephination were also identified.CONCLUSIONS:
Marked loss of the corneal endothelium is the prominent feature of primary DSAEK graft failure. Examples of surgical features, such as incomplete Descemet's stripping and residual full-thickness cornea with a DSAEK graft, are shown.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Corneano
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Transplante de Córnea
/
Lâmina Limitante Posterior
/
Rejeição de Enxerto
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Ophthalmology
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos