Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update.
Gastroenterol Clin Biol
; 32(6 Suppl 1): 8-21, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18973843
ABSTRACT
This review summarizes the methodological aspects of the interpretation of non-invasive biomarkers in liver fibrosis. A scoring system has been updated to better compare the quality of fibrosis biomarkers. Several methodological issues are related to the classical methodology using biopsy, as this is considered the gold standard. However, from evidence-based data, it appears that the methodology needs to change to prevent flawed conclusions among key opinion leaders as well as in obsolete guidelines. As waiting for the perfect biomarker for the diagnosis of advanced fibrosis to come along is probably a waste of time, in the meantime, methods can be improved. The main proposals for improving the methodology are, to take into account the spectrum bias, to assess accuracy between adjacent stages, to compare biomarkers in the same patient, to assess the cause of failure among discordant cases and to use specific statistical methods adapted for imperfect gold standards.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cirrose Hepática
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
Gastroenterol Clin Biol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França