Hydrogen peroxide reduces lead-induced oxidative stress to mouse brain and liver.
Bull Environ Contam Toxicol
; 82(4): 419-22, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-18974911
ABSTRACT
Lead (Pb) intoxication may initiate many disorders in human and animals. This study investigates the role of exogenous hydrogen peroxide (H(2)O(2)) in inducing mouse tolerance to Pb exposure. Results showed that the simultaneous application of 1.2 microg H(2)O(2) per kg body weight efficiently protected mice against the Pb-caused injury, as revealed by decreased growth suppression caused by the Pb stress, increased antioxidative enzyme activity, reduced lipid peroxidation, and the protective effect on the nuclear DNA integrity. To our knowledge, this is the first finding of this sort.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Oxidantes
/
Estresse Oxidativo
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Peróxido de Hidrogênio
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Intoxicação por Chumbo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Bull Environ Contam Toxicol
Ano de publicação:
2009
Tipo de documento:
Article